CMC Microsystems
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Michael Overduin

Professor, Department of Biochemistry

University of Alberta

Michael has over 25 years of biotechnology and structural biology experience, having launched drug discovery projects focussed on novel kinase and phosphatase signaling targets and invented the SMALP system for analysis of membrane protein targets in native nanodiscs. He is a Professor in the Department of Biochemistry at the University of Alberta. He founded the SMALP Network, an open innovation community for developing native nanodisc technology, and DiscoveryLab, which supports the commercialization of novel research products by linking researchers and business mentors. He was previously Professor of Structural Biology and Director of the Henry Wellcome Building for NMR, a UK national facility, established his first lab at the University of Colorado in Denver, postdoc’ed at the University of Toronto and obtained his PhD at The Rockefeller University.

Sessions Michael Overduin is a part of

Wednesday, June 8, 2022

What will it take to make personalized and precision medicine mainstream within 15 years?

2:00 pm to 3:30 pm
in Salon 9

Talk Description

Membrane nanodisc technology and new concepts for targeted drug discovery

My lab determines how proteins recognize lipid signals within biological membranes. We use structural biology methods to elucidate structures. The interactions of lipids, micelles, and nanodiscs are compared to resolve membrane-associated protein structures and discover lipid ligands responsible for directing cellular functions. Our discoveries of the phosphoinositide ligands of signaling domains have defined new principles of membrane trafficking of eukaryotic, bacterial, viral, and prion proteins. This in turn is extending the central dogma of molecular biology to include membrane structure and function. Tools being developed include a library of polymers for the study of native membrane protein assemblies including prions, and algorithms for identification of membrane docking areas on any protein structure. Applications include the identification of novel pockets for the design of drug candidates which are specific for therapeutic target states including of CoV spike proteins.

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